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When RBC in circulation bump into macrophages, CD47 actively prevents engulfment by binding to SIRPα on macrophages and this interaction provides a “do not eat me signal” [for a review see reference Matozaki et al

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Comparatively, lentiviral Nrf2 overexpression caused significant improvements in observed learning deficits in a mouse model of Alzheimer's disease, accompanied by decreased amyloid plaque burden [28]