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For macrophage phenotype regulation, Mn 2+ /glycyrrhizic acid self-assembled hydrogels (MnGAHs) remove excess ROS by mimicking Mn-SOD enzymatic activity and downregulate the hypoxia-inducible factor-1 alpha (HIF-1α) pathway, promoting the transformation of pro-inflammatory M1 macrophages to repair-type M2 macrophages (increasing the proportion of CD206 + cells to 68%), thereby significantly enhancing IL-10 secretion ( 19
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Regular nutritional monitoring and blood tests can help identify deficiencies early