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Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks.

There can be secondary benefits to overall health and wellness markers when deficiency is corrected: better training quality, more stable mood, fewer days lost to drag

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▪ Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F) and use within about 28 days