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Disulfiram commonly causes fatigue, sleepiness, headaches, and a metallic taste, although more severe reactions including dermatological, hepatic (hepatitis, hepatotoxicity), cardiac, neurological (peripheral and/or axonal polyneuropathy, sensory-motor polyneuropathy, optic neuritis, seizures), and psychiatric (confusion, psychosis) reactions, may result [112]
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The reason for diminished endothelial nitric oxide release in skin grafts is not known