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Critically, this mechanism is selective for senescent cells because non-senescent cells do not accumulate FOXO4 in PML bodies and do not depend on FOXO4-p53 sequestration for survival
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While testosterone is generally associated with anxiolytic and antidepressant effects—mediated in part via aromatization into estradiol in the dentate gyrus and binding to androgen receptors in brain regions such as the basolateral amygdala and the suprachiasmatic nucleus [285,286,287]—increased anxiety and depressive symptoms have nonetheless been reported in chronically infected individuals, see Section 5.5 and Section 5.6
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