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50 years on, over 60% of women of reproductive age worldwide are using some form of contraception

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In persons with intestinal lesions such as jejunal diverticulosis or some anatomical abnormalities with bacterial over­growth (e.g., fistulas and blind-loops), vitamin B12 defi­ciency may develop because bacteria in the colon competitively utilize all the available vitamin B12 (Cooke et al., 1963)