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The induction of nitric oxide synthase type 2 leads to increased nitric oxide levels and S -NO of cysteine residues ( S -NO sites on Cys residues of NOS2-dependent S -NO of synaptic proteins in mild cognitive impairment (MCI) and AD and human control brain tissues ( S -NO proteins identified in synaptosome fractions, 16 and 9 S -NO proteins were significantly increased in AD vs