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Unfortunately, the compounds suffer from poor in vitro metabolic stability ( Direct Design From the Structure of Insulin-Regulated Aminopeptidase In 2013, laboratories in Greece and Stratikos’ and Georgiadis’ groups reported that the phosphinic pseudotripeptide 43 (DG013A) is a potent inhibitor of IRAP with an IC50 of 57 nM (Figure 11)
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