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In vitro, GADD45β overexpression in HepG2 cells significantly suppressed fatty acid-induced expression of these genes, whereas GADD45β knockdown enhanced their expression and lipid accumulation

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One study revealed that copper ions bind to the histidine residues of Aβ, forming a non-β-folded Aβ/Cu complex that inhibits fibrillization and blocks the formation of typical amyloid fibrils (70)