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The regularization parameters include the sparsity of \( {\boldsymbol{u \) and \( {\boldsymbol{v \), which were determined by the following grid-search and nested cross-validation procedure within the training dataset

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IGF-1 — acting through the IGF-1 receptor and downstream PI3K–Akt–mTOR and MAPK signalling cascades — mediates the principal anabolic, growth-promoting, and tissue-remodelling effects of the GH/IGF-1 axis