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Moreover, the proteolytic activity of the proteasome requires catalysis by the intact sulfhydryl groups of Cys residues in the β subunit of the 20S core, which is susceptible to oxidative stress [26]

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Signs of Deficiency (Ariboflavinosis) Riboflavin deficiency, known as ariboflavinosis , develops gradually and usually shows up first in the mouth, skin, and eyes — angular cheilitis (cracked mouth corners), a swollen magenta tongue, seborrheic dermatitis, light sensitivity, fatigue, and iron-resistant anemia