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And the political pressure shaping the July meeting's composition and likely direction raises legitimate questions about whether the process will produce a scientifically grounded outcome

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Accordingly, the approach is to fine-tune substrate entry and ΔΨm (e.g., adjust succinate/fatty-acid flux, avoid excessive hyperpolarization), limit RET in high-risk windows, reinforce mitochondrial quality control (biogenesis and mitophagy to cull ROS-prone organelles) and buffer Ca²⁺ transfer at MAMs to prevent feed-forward ROS/Ca²⁺ loops—favoring these node- and compartment-specific levers over blanket antioxidant suppression (Brand et al