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There are eight isoforms of vitamin E: four tocopherols (α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol) and four tocotrienols (α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol), α- tocopherol being the most potent and abundant isoform in biological systems

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Members of the Dkk class bind to LRP5/6 component of the Wnt receptor complex to inhibit (Dkk-1, -2, -4) or activate (Dkk-3) canonical Wnt signaling [30], with one of the best characterized members being Dkk1