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Little or no tumor specificity, poor tumor penetration, cancer cell heterogeneity, insufficient drug accumulation into the tumors abound with the development of multidrug resistance (MDR) conferred by many factors, and finally, undesirable side effects are all crucial matters that contribute to the lack of effectiveness and eventually therapeutic failure observed in conventional cancer therapeutics
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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
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