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In the C26 colon carcinoma mice model, pathologically elevated serum Phe concentrations show a significantly negative correlation with body weight, implying that circulating Phe levels may serve as a viable biomarker for predicting tumor progression and evaluating the severity of cachexia (113)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Soriano P Generalized lacZ expression with the ROSA26 Cre reporter strain