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Interestingly, metformin is preferentially accumulated in KRAS mutation mCRC cells, but not wild-type ones, in both primary cell cultures and patient-derived xenografts, which is in agreement with its tremendous effect in KRAS -mutation mCRC patients

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As the principal intracellular antioxidant, GSH reduces lipid peroxides to less toxic alcohols, thereby limiting lipid peroxidation damage (65, 66)