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Th2 response is triggered by Th2 cells activation, IL-4, IL-5, IL-13 release, as well as eosinophil promotion, and subsequent IgE production (272, 276–278), whereas Treg cells shift the response toward immunosuppressive phenotype through IL-10 and TGF-β cytokines, which may be induced directly by the helminth or through the microbiome (279, 280)
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The endometrium is highly responsive to cyclic changes in the ovarian steroid hormones estradiol and progesterone, which largely exert their effects via their cognate nuclear receptors and downstream regulation of gene transcription within multiple cellular compartments of the endometrium (Jain et al., 2022)