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The findings suggest that optimizing the Ca:Mg intake ratio through magnesium supplementation can enhance gut microbial diversity and metabolic activity, thereby supporting gut health
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More recently, urea-based and pyrazolidine CypD inhibitors with nanomolar affinity have shown robust protection of pancreatic mitochondria and tissue architecture in cerulein- and bile acid-induced AP, confirming that mPTP inhibition is a druggable node that functionally stabilizes mitochondrial–ER Ca 2+ crosstalk, ROS generation, and cell-death patterns