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The pro-apoptotic BCL2-associated X, apoptosis regulator (BAX) protein is increased under oxidative stress and reduces membrane permeability 32

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Cryoelectron microscopy of human ABCB6 has recently delineated the structural mechanism of ABCB6 for porphyrin transport, although the specific substrate for this transporter is debatable since it has been implicated in cadmium detoxification (108, 125)