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New Insights on the Etiopathogenesis of Vitiligo | Actas Dermo-Sifiliográficas
These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )
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In these tissues, iron is also present in iron-sulfur (Fe-S) clusters, and it serves as a cofactor to support ETC, respiration, and oxygen transport (reviewed in Rouault, 2012)
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