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Once activated, NLRP3 inflammasome components drive sustained IL-1β and IL-18 release, which recruit and activate neutrophils and monocytes while IL-1β promotes vascular permeability and leukocyte infiltration, and IL-18 enhances IFN-γ production—together forming an inflammatory amplification loop that perpetuates chronic inflammation and obstructs healing (Wang et al., 2025a) (Figure 3)

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