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There are several low frequency variants of ALDH1A1 that have been nominally associated with alcoholism-related phenotypes, including ALDH1A*2 , a 17 bp promoter deletion, and ALDH1A*3 , a 3 bp promoter insertion 5 that showed a weak trend toward association with alcoholism in African Americans (Spence et al., 2003)

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It activates AMP-activated protein kinase (AMPK) pathways involved in energy homeostasis and lipid metabolism, promoting fat oxidation and lipolysis in adipose tissue