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Symptoms of vitamin B12 and folic acid deficiency anemia include: – Shortness of breath – Headache – Indigestion – Loss of appetite – Heart palpitations – Vision problems – Feeling weak or tired – Diarrhea – Pain or redness of the tongue, sometimes with mouth sores – Problems with memory, comprehension, and judgment (cognitive changes) Some of these symptoms may also occur in people who are deficient in vitamin B12 or folic acid but are not anemic

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The evidence is preclinical — mouse and cell studies