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After administration of the high dermal doses sufficient to prostrate the female C3H mice within 30 min, the blood became chocolate coloured and more viscous at 1–3 h after exposure, and the skin developed a dark grey-blue hue

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The AUC brain /AUC plasma for the more polar 7-hydroxymitragynine was 100 μ M) (Abdullah and Ismail, 2018) (Table 4)