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Crystallization KRAS-Q61K bound by GDP purified by SEC was diluted to 100 µM in buffer (12.5 mM HEPES, pH 7.4, 75 mM NaCl, 2 mM MgCl 2 , 2 mM AlCl 3 and 100 mM NaF) and was incubated with 300 μM compound 2 (3% DMSO in total) for 10 min on ice
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