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DIHEXA has the potential advantage over BDNF itself in that, as a smaller peptide, it may have a better ability to cross the blood-brain barrier, reaching where it is needed

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In one study, the coculture of melanoma cells with peripheral blood mononuclear cells (PBMCs) from healthy volunteers demonstrated the former’s ability to suppress the IFN response in PBMCs, an effect that was negatively correlated with NOS1 expression (Liu, Tomei et al