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Isotope-labeled internal standards ( 13 C, D) were employed to ensure accurate quantification: acetaminophen D4, atorvastatin D5, bisoprolol D5, clindamycin D3, erythromycin C13 D3, fluoxetine D5, metformin D6, mycophenolic acid D3, salbutamol D7, sulfamethoxazole D4, trimethoprim D9, valsartan D3

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These findings reveal the causative mechanisms of IFN-I-dependent pro-inflammatory response even in the absence of HIV-1 replication in PLWH [41, 142]