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GSTs are mainly homo- or heterodimeric enzymes, where each subunit contains an N-terminal thioredoxin (TRX) domain linked to an α-helical C-terminal domain [14,210,219]

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In the current study, in male and female mice, we administered the first GHSR inverse agonist, PF-5190457, which progressed to clinical development, and was found well-tolerable by oral administration in humans 31,32