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TNF- α is an inflammatory molecule that mediates hepatic injury, and it has been reported that Atg-7 deficiency led to hepatic injury upon administration of common hepatic toxicants including galactosamine combined with LPS/galactosamine with TNF- α to mice [149]
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A main difference between senolytics and senomorphic drugs from a therapeutic perspective is the timeframe of administration of the therapy: while senolytics show efficacy with intermittent administration, treatment with senomorphics need to be continuous to maintain the suppression of the SASP
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